marigday: মে 2013

মঙ্গলবার, ১৪ মে, ২০১৩

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Doctors can't inject cancer patients with intelligent nanobots programmed to launch surgical counterstrikes against the disease. That didn't stop a team of medical researchers and software programmers from developing a video game several years ago that helped young patients imagine such an empowering scenario. Based on the success of that project, the team recently launched a sequel geared for mobile devices that they hope will further encourage kids undergoing chemotherapy and other treatments to better understand what's happening inside their bodies and how they might regain their health. Re-Mission 2 is a collection of six free online games--accessible via Web browser or Apple iPad--that share the theme of taking the fight to cancer. They do this by arming patients with a virtual arsenal of chemo, radiation and targeted cancer drug attacks designed to crush advancing malignant forces. The game--and its 2006 predecessor Re-Mission--are the product of HopeLab, a nonprofit founded in 2001 by Pamela Omidyar, wife of eBay founder Pierre Omidyar. It's hard to deny that a diversion such as "Stem Cell Defender," in which players protect white blood cells from a bacteria invasion by unleashing antibiotic bombs, could do wonders for a child's morale during long waits at a doctor's office or hospital. (Bacterial infections, nausea and constipation are some treatment-related effects patients may experience.) HopeLab, however, insists the games do more even more than this, claiming they improve treatment outcomes by educating young patients about the disease and how it can be fought. Such knowledge makes these patients more likely to adhere closely to their treatment regimens. HopeLab has backed this claim over the past few years with a number of studies, although the organization is careful not to directly associate game play with actual cancer remission. In the most recent study, HopeLab worked with Stanford University associate professor of psychology and neuroscience Brian Knutson on a functional magnetic resonance imaging (fMRI) study analyzing brain regions activated when people play the original Re-Mission. The paper, published in the March 2012 PLoS ONE, compared brain scans in 57 cancer-free undergraduates who were randomly assigned to actively play Re-Mission or passively watch the game. Re-Mission players experienced more activity in neural circuits associated with incentive motivation when compared to those who merely observed game play. Such reward-related activation could shift attitudes and emotions and boost players' adherence to prescribed chemotherapy and antibiotic treatments to fight infection, the researchers said, although they acknowledge that further tests are needed on actual cancer patients before they can read too much into the results. An earlier study published in the journal Pediatrics in August 2008 (pdf) sought to determine whether video games could encourage adolescent and young-adult cancer patients to more consistently take self-administered treatments such as oral chemotherapy, a particularly difficult problem in that age group. The study--which included 374 adolescents and young adults with malignancies including acute leukemia, lymphoma, and soft-tissue sarcoma--found that those who played Re-Mission took their medication more consistently, increased their knowledge of the disease and generally played a more active role in their treatment (pdf). Although that study was led by principal investigator and former HopeLab president and CEO Pamela Kato, it also included researchers from West Virginia University and the University of Texas Health Science Center. Re-Mission 2 caters to kids who have grown up playing Angry Birds, Fruit Ninja and other games on the Internet or via apps on their mobile devices. In fact, the sequel can be played only online or on the iPad. HopeLab is working on versions that will work on Android devices. This is a calculated switch from the format of the original version of Re-Mission, which took players on a quest heavily influenced by popular video games at the time, most notably Tomb Raider. Instead of Lara Croft, Re-Mission featured a microscopic robot named Roxxi, clad in form-fitting silver body armor, who traveled through the bodies of fictional cancer patients, blasting cancer cells and battling the side-effects of cancer and its treatments. The Re-Mission re-boot is a welcome change, says Brooke Jaffe, a 21-year-old junior at Barnard College in New York City. Quest games like Tomb Raider that are played on PCs and video game consoles like Xbox or the Wii can be intimidating to people who don't already play them, adds Jaffe, an English major who became aware of HopeLab's work after she was successfully treated for papillary carcinoma--thyroid cancer--in 2011. Re-Mission 2 is a much more casual approach to gaming. It may not have the complicated 3-D graphics and the emphasis on anatomical realism of its predecessor, but it's certainly more accessible to a kid waiting to undergo treatment, or who is fatigued from having just undergone treatment, says Jaffe, one of 120 teens and young adults HopeLab recruited to help develop and evaluate Re-Mission 2. The idea is that patients will get a lot more enjoyment from playing 10 minutes of one of Re-Mission 2's simpler games than they would from 10 minutes of the original version, which might require 30 minutes of play to get past the first level. Images courtesy of HopeLab Follow Scientific American on Twitter @SciAm and @SciamBlogs. Visit ScientificAmerican.com for the latest in science, health and technology news.
? 2013 ScientificAmerican.com. All rights reserved.

Source: http://news.yahoo.com/video-game-help-kids-fight-cancer-214900242.html

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Bangladesh collapse search over; death toll 1,127

SAVAR, Bangladesh (AP) ? Several major Western brands embraced a safety plan that requires retailers to help pay for factory improvements in Bangladesh, where the three-week search for bodies at the site of the world's worst garment-industry disaster ended Monday with the death toll at 1,127.

The collapse on April 24 of the Rana Plaza factory building focused worldwide attention on the hazardous conditions in Bangladesh's low-cost garment industry and strengthened pressure for reforms.

Bangladesh's government also agreed Monday to allow garment workers to form trade unions without permission from factory owners. That decision came a day after it announced a plan to raise the minimum wage for garment workers. Both moves are seen as a direct response to the collapse of the eight-story building, which housed five clothing factories.

Swedish retailing giant H&M, the largest purchaser of Bangladesh garments, and Britain's Primark Stores announced Monday that they have accepted a legally binding fire and building safety plan drawn up by Bangladeshi and international labor groups. The plan would establish an independent inspectorate to oversee factories, with powers to shut down unsafe facilities and require renovations financed in part by Western retailers.

The Clean Clothes Campaign, which seeks better working conditions in the global garment industry, praised H&M's decision, saying it would pressure other retailers to sign the plan as well.

The agreement was signed earlier by two other companies ? PVH, the owner of the Tommy Hilfiger and Calvin Klein brands, and German retailer Tchibo. Others, however, had refused to sign because the plan was legally binding and costly.

Primark is one of the few retailers that have acknowledged that their clothes were being made by factories in the Rana Plaza building at the time of the collapse.

Working conditions in the $20 billion industry are grim, a result of government corruption, desperation for jobs, and industry indifference. Minimum wages for garment workers are among the lowest in the world at 3,000 takas ($38) a month.

Mohammed Amir Hossain Mazumder, deputy director of fire service and civil defense, said the search for bodies at Rana Plaza was called off at 6 p.m. Monday.

"Now the site will be handed over to police for protection. There will be no more activities from the fire service or army," he said.

Bulldozers and other vehicles have been removed from the building site, which will be fenced with bamboo sticks. Red flags were erected around the site to bar entry.

Reshma Begum, 19, rescued from the rubble of the Rana Plaza building 17 days after the building collapsed, speaks during a media conference at Savar Combined Military Hospital in Savar May 13, 2013. ... more? Reshma Begum, 19, rescued from the rubble of the Rana Plaza building 17 days after the building collapsed, speaks during a media conference at Savar Combined Military Hospital in Savar May 13, 2013. Bangladeshi salvage workers neared on Monday the end of their search for victims of the collapse of a factory building, scouring the basement of the complex that crumbled in on itself killing 1,127 people. REUTERS/Khurshed Rinku (BANGLADESH - Tags: DISASTER SOCIETY TPX IMAGES OF THE DAY) less? The last body was found on Sunday night. A special prayer service will be held Tuesday to honor the dead, said army Brig. Gen. Mohammad Siddiqul Alam Shikder.

For more than 19 days, Rana Plaza in the Dhaka suburb of Savar had been the scene of frantic rescue efforts, anguished families and the overwhelming smell of decaying flesh.

Miracles were few, but on Friday, search teams found Reshma Begum, a seamstress who survived under the rubble for 17 days on cookies and bottled water.

Begum spoke to reporters Monday from the hospital where she is being treated. She told them she never expected to be rescued alive, and she vowed, "I will not work in a garment factory again."

The Rana Plaza owner and eight other people, including garment factory owners, have been detained in the collapse investigation. Authorities say the building owner added floors to the structure illegally and allowed the factories to install heavy equipment that the building was not designed to support.

Bangladesh's Cabinet approved an amendment to the 2006 Labor Act on Monday lifting restrictions on forming trade unions in most industries, government spokesman Mosharraf Hossain Bhuiyan said. The old law required workers to obtain permission before they could unionize.

"No such permission from owners is now needed," Bhuiyan told reporters after the Cabinet meeting presided over by Prime Minister Sheikh Hasina. "The government is doing it for the welfare of the workers."

Local and international trade unions have long campaigned for such changes.

Though the 2006 law technically allowed trade unions ? and they exist in many of Bangladesh's other industries ? owners of garment factories never allowed them, saying they would lead to a lack of discipline among workers.

Trade union leaders responded cautiously.

"The issue is not really about making a new law or amending the old one," said Kalpana Akter of the Bangladesh Center for Workers Solidarity, a group campaigning for garment workers' rights. "In the past whenever workers tried to form associations they were subjected to beatings and harassment," she said. "The owners did not hesitate to fire such workers."

Bangladesh's government has in recent years cracked down on trade unions attempting to organize garment workers. In 2010 Hasina's government launched an Industrial Police force to crush street protests by thousands of workers demanding better pay and working conditions.

That year police arrested at least six activists, including Akter, on charges of instigating workers to vandalize factories. They were later freed, but some charges are still pending.

The activists are also angry that police have made no headway in the investigation of the death of a fellow union organizer, Aminul Islam, who was found dead a day after he disappeared from his home in 2012.

"Islam's case is going nowhere even though police say they are investigating," said Akter.

On Monday, nearly 100 garment factories shut down in the Ashulia industrial area near Dhaka after protests erupted over the death of a female worker whose body was found inside a garment factory.

The body of Parul Akter, 22, was found on Friday. A local police official, Badrul Alam, said she committed suicide.

Thousands of workers took to the streets Monday and vandalized vehicles and shops before police used sticks to disperse the protesters. Several people were injured, said a police official who spoke on condition of anonymity because he was not authorized to speak publicly.

Bangladesh has 5,000 garment factories and 3.6 million garment workers. It is the third-biggest exporter of clothes in the world, after China and Italy. China lacks independent labor unions for all industries; the only legal unions are controlled by the Communist Party, and workers complain that they fail to represent their interests.

On Sunday, the Bangladesh government set up a new minimum wage board that will issue recommendations for pay raises within three months, Textiles Minister Abdul Latif Siddiky said. The Cabinet will then decide whether to accept those proposals.

The wage board will include representatives of factory owners, workers and the government, he said.

Government officials also have promised improvements in safety. Since 2005, at least 1,800 garment workers have been killed in factory fires and building collapses in Bangladesh, according to research by the advocacy group International Labor Rights Forum.

In November, 112 workers were killed in a garment factory in Dhaka. The factory lacked emergency exits, and its owner said only three floors of the eight-story building were legally built.

___

Hossain reported from Dhaka. Associated Press writer Matti Huuhtanen in Stockholm contributed to this report.

Source: http://news.yahoo.com/bangladesh-collapse-search-over-death-toll-1-127-122554495.html

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শনিবার, ৪ মে, ২০১৩

Campaign finance within constitutional bounds | Harvard Gazette

Obert C. Tanner, a jewelry store magnate who grew up herding sheep in Utah, put himself through college in the 1920s by getting up early every morning to light furnace fires. He died in 1993, but his philanthropy is still creating light and heat, predominantly through the Tanner Lectures on Human Values. Established in 1976, they are delivered annually at nine universities.

At Harvard this year, the Tanner Lectures were delivered May 1-2 by Dean Robert C. Post of Yale Law School. He took up an issue that generates a lot of heat but could use some extra light: the constitutional debate over campaign finance reform.

In 2010 the Supreme Court ruled on Citizens United v. Federal Election Commission, a case so starkly contentious that ?constitutional arguments slide past each other with scarcely a moment of mutual engagement,? said Post. The issue centered on a single question: Should corporations be allowed to give political campaigns unlimited amounts of money? The Supreme Court, by 5-4, said yes.

At issue was the constitutionality of section 441b of the Bipartisan Campaign Reform Act of 2002, which banned corporations from funding ?electioneering communication.? But a majority of the justices wondered: What was the government?s ?compelling interest? in requiring the prohibition? Didn?t it violate free speech?

Arguments in favor of the reform law cited ?three major state interests,? said Post: to promote equality, to remove the ?distortion? that immense corporate wealth could invite, and to eliminate corruption. In the end, though, none of these interests was powerful enough in constitutional terms to sway a majority of justices.

To this day, Post said in his opening lecture, campaign finance reform remains ?among the most vexing constitutional issues of our time.? Reformers still call the influx of cash a threat to political integrity. Advocates still argue that limiting contributions would limit free speech.

Constitutional law ?is meant to affirm common principles of agreement,? said Post. But Citizens United was ?instantly controversial and unpopular,? he said, and merely hardened positions in an already intractable debate. The majority opinion held that it was ?stranger than fiction for our Government to make ? political speech a crime.? On the other side, one critic declared that Citizens United ?practically supplanted Dred Scott as the worst Supreme Court decision of all time.? The line was so bright between the two sides, said Post, it was as if they ?inhabited entirely different constitutional universes.?

He called the divide ?a horrifying disjunction,? but offered two reasons why it was a reality. For one, the Supreme Court has so far failed to clearly explain First Amendment jurisprudence, and for 80 years or more has relied on abstractions and rhetoric. So it is not possible for the court to ?think carefully? about First Amendment principles and how they can be reconciled with campaign finance reform, said Post.

For another, he said, jurists who favor campaign finance reform have so far failed to show how the idea of such regulation is compatible with the idea of free speech.

To smooth the waters, Post offered his Tanner Lectures ? rapidly paraphrased from a version 158 pages long, with copious footnotes ? as a way for constitutional scholars to find common ground and to recast the debate. Perhaps ?practical reform? would result from his Tanner ideas someday, said Post, but that was not his intent; nor would the lectures offer a concrete plan for mobilizing change.

Instead, he offered a strategy to get to common ground. First, establish that the First Amendment?s purpose is to make self-government possible. After all, he said, the 18th century bedrock of the United States was ?the premise of self-government? and ?the value of self-determination? ? reactions to coercive and unrepresentative British rule.

After that, establish ?a managerial domain? within the First Amendment ? a way that ?speech may be regulated as necessary to maintain the fundamental constitutional value of electoral integrity,? he said.

Without a sense of electoral integrity, ?we are at risk,? said Post, especially in an era of increasingly expensive electoral contests. ?The public cannot help but worry that he who pays the piper will call the tune.?

Source: http://news.harvard.edu/gazette/story/2013/05/campaign-finance-within-constitutional-bounds/

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U.S. Cellular will begin selling Apple products later this year

U.S. Cellular, the fifth-largest carrier in the United States, will start selling Apple products later this year. Announcing their Q1 financial results, the carrier said that they hope that adding Apple products to their lineup will help convice people to switch.

We have a number of strategies in progress to increase loyalty and attract more customers, including our announcement today that we will begin offering Apple products later this year. By further strengthening our device portfolio, we'll give consumers another great reason to switch to U.S. Cellular, and enable our existing customers to choose from an even wider variety of iconic smartphones, and enjoy the outstanding U.S. Cellular customer experiences they deserve.

These products surely include at least one model of iPhone, and possibly the iPad. U.S. Cellular currently sells several different Android tablets, so adding the iPad to their lineup wouldn?t be a stretch. Specific availability of Apple?s devices on the carrier wasn?t announced.

U.S. Cellular will be the latest carrier in the United States without national coverage to get Apple devices, a group that has been expanding rapidly over the last couple of years. While most of their customers come from the four major carriers, Apple wants the iPhone in as many hands as possible, and the small and mid-sized carriers like U.S. Cellular allow them to do just that, offering better prices on plans while still selling a device as great as the iPhone.

Source: PRNewswire

Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/0d9Lsvit1UI/story01.htm

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শুক্রবার, ৩ মে, ২০১৩

Potential novel treatment for influenza discovered: Scientists pursue new therapies as deadly H7N9 flu spreads in China

May 1, 2013 ? An experimental drug has shown promise in treating influenza, preventing lung injury and death from the virus in preclinical studies, according to University of Maryland School of Medicine researchers publishing in the journal Nature on May 1. The scientists found that a drug called Eritoran can protect mice from death after they have been infected with a lethal dose of influenza virus. The potential value of this drug as single therapy or in combination with antivirals is further supported by previous research that found that it is safe for use in humans.

The findings are of particular interest to scientists now that the latest deadly strain of flu, H7N9, is spreading in China -- 82 people in China had been infected with the new strain of flu virus as of April 26, and 17 had died.

Previous scientific studies have revealed that acute lung injury caused by the influenza virus is the result of an immune reaction mediated by a protein called Toll-like receptor 4 (TLR4). Senior author Stefanie Vogel, Ph.D., Professor of Microbiology and Immunology and Medicine at the University of Maryland, and colleagues previously demonstrated that mice that lack the ability to signal through TLR4 are highly refractory to influenza-induced lethality. In their new study, they extend these findings by showing that Eritoran -- a synthetic inhibitor of TLR4, originally developed by Eisai Inc. for treatment of sepsis -- improved clinical symptoms and prevented death when administered up to six days after infection with the influenza virus. Existing antiviral medications must be administered within two days of infection to be optimally effective.

Annual influenza epidemics are estimated to result in 3 million to 5 million cases of severe illness and 250,000 to 500,000 deaths yearly worldwide. The virus is continually evolving and new variants give rise to seasonal outbreaks. Increasing resistance to existing antiviral therapies and the short time-frame in which these agents are effective highlight the critical need for new treatments, such as Eritoran. This study was funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

"Currently, vaccines and antiviral medications are the two main approaches to preventing influenza," says Dr. Vogel. "Problems associated vaccine development may limit efficacy and/or vaccine availability. In addition, people suffering from influenza may not go to the doctor or to the emergency room in time for the antivirals to be effective. Also, as the flu adapts to resist existing treatments, we are in search of new therapies to save lives and prevent severe illness. Our research seems to show that Eritoran could provide doctors with a new tool in their flu-fighting toolbox, as well as several more days to treat the sickest of patients successfully. More basic research is needed, but we are hopeful that this medication could one day change the way that we treat severe influenza and possibly other pathogens that cause disease by a similar mechanism."

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The above story is reprinted from materials provided by University of Maryland Medical Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Kari Ann Shirey, Wendy Lai, Alison J. Scott, Michael Lipsky, Pragnesh Mistry, Lioubov M. Pletneva, Christopher L. Karp, Jaclyn McAlees, Theresa L. Gioannini, Jerrold Weiss, Wilbur H. Chen, Robert K. Ernst, Daniel P. Rossignol, Fabian Gusovsky, Jorge C. G. Blanco, Stefanie N. Vogel. The TLR4 antagonist Eritoran protects mice from lethal influenza infection. Nature, 2013; DOI: 10.1038/nature12118

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/Gg2NTwnMfBU/130501154440.htm

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বৃহস্পতিবার, ২ মে, ২০১৩

Increases in heart disease risk factors may decrease brain function

May 2, 2013 ? Brain function in adults as young as 35 may decline as their heart disease risk factors increase, according to new research in the American Heart Association journal Stroke.

"Young adults may think the consequences of smoking or being overweight are years down the road, but they aren't," said Hanneke Joosten, M.D., lead author and nephrology fellow at the University Medical Center in Groningen, The Netherlands.

"Most people know the negative effects of heart risk factors such as heart attack, stroke and renal impairment, but they do not realize it affects cognitive health. What's bad for the heart is also bad for the brain."

The Dutch study included 3,778 participants 35- to 82-years-old who underwent cognitive function tests that measure the ability to plan and reason and to initiate and switch tasks. A separate test gauged memory function. The Framingham Risk Score determined their risk for cardiovascular events in the next 10 years.

Researchers found:

Participants with the most heart disease risks performed 50 percent worse on cognitive tests as compared to participants with the lowest risk profile.
The overall Framingham Risk Score, age, diabetes, bad cholesterol and smoking were negatively linked to poor cognitive scores.
Compared to non-smoking participants, those who smoked one to 15 cigarettes daily had a decrease in cognitive score of 2.41 points and those smoking more than 16 cigarettes daily had a decrease of 3.43 points. The memory scores had a similar association.
Two risk factors -- smoking and diabetes -- were strong determinants of cognitive function.

"There clearly is a dose response among smokers, with heavy smokers having a lower cognitive function than light or non-smokers," Joosten said. "It is likely that smoking cessation has a beneficial effect on cognitive function."

Health professionals need to be aware of cognitive function in patients with risk factors for cardiovascular disease. Cardiovascular risk factors, especially those that are modifiable like smoking and obesity, need ongoing attention from the medical profession, government and food industry, she said. "Smoking cessation programs might not only prevent cancer, stroke and cardiovascular events, but also cognitive damage."

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The above story is reprinted from materials provided by American Heart Association.

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Journal Reference:

Hanneke Joosten, Marlise E.A. van Eersel, Ron T. Gansevoort, Henk J.G. Bilo, Joris P.J. Slaets, and Gerbrand J. Izaks. Cardiovascular Risk Profile and Cognitive Function in Young, Middle-Aged, and Elderly Subjects. Stroke, May 2 2013 DOI: 10.1161/STROKEAHA.111.000496

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/MliXYGXEeaE/130502185421.htm

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Next BoE chief Carney signals flexibility on inflation target

EDMONTON, Alberta (Reuters) - The next Bank of England governor, Mark Carney, endorsed on Wednesday the idea of sometimes letting inflation run above target for longer than normal, while also warning of the risks to credibility if this is taken too far or done too often.

Carney, governor of the Bank of Canada till June 1, sang the praises of flexible inflation targeting, saying tighter monetary policy might be needed to prevent imbalances from developing and looser policy might be needed to avoid further damage to the economy.

The Bank of England has let inflation run above its 2 percent target even while it pursues an extraordinary amount of monetary easing, keeping interest rates at 0.5 percent for four years and engaging in buying massive amounts of government debt in a bid to spur economic growth.

"The weakness of growth since quantitative easing was introduced is not itself a reason to doubt that it is an effective policy," he said in a lengthy lecture in Edmonton, Alberta, examining the lessons learned from five years of financial turmoil.

But he acknowledged limits to flexible targeting. "The time frame for returning inflation to target can be stretched, but the credibility essential for the success of such a tactic could be undermined if such flexibility is taken too far, deployed too frequently or undertaken by stealth," he said.

Carney said asset purchase programs by the U.S. Federal Reserve and the Bank of England have had positive effects on financial markets, but that it was more difficult to judge how these effects were transmitted to the broader economy.

He made no specific remarks about whether the BoE should expand its asset purchase program or pursue other forms of unconventional policies. Nor did he provide any new guidance on Canadian policy, other than to repeat that household debt levels were stabilizing, in part due to the bank's rate-hike talk since last April.

He said central banks that have provided forward guidance, such as the Fed's policy of setting a threshold for unemployment, have helped provide further stimulus to economies. Such policies, which are now being debated in Britain, can lead to lower long-term nominal rates and reinforce their stimulative effect, he said.

While price stability should remain the primary objective of monetary policy it does not guarantee financial stability and might even promote financial instability over the medium term, Carney said.

The lecture was his penultimate speech as Bank of Canada governor before he steps down to run the Bank of England starting in July. Carney's successor is expected to be named shortly.

(Reporting by Louise Egan and Randall Palmer; Editing by Lisa Shumaker)

Source: http://news.yahoo.com/next-boe-chief-carney-signals-flexibility-inflation-target-215237395.html

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CSN: Cubs threaten move? |? Unveil Wrigley plans

Tom Ricketts finally played the card used by so many other owners in professional sports: The threat to move.

While it still seems unthinkable that the Cubs would actually leave Wrigley Field, Ricketts opened up that possibility on Wednesday for the first time. As the $500 million renovation project moved into the public-approval phase, the chairman went all-in with the Jumbotron.

[RELATED: Proposed Cubs restoration plan]

?If we don?t have the ability to generate revenue in our own outfield, then we?ll have to take a look at moving,? Ricketts said. ?No question.?

Ricketts ? who associates have described as sometimes being too nice of a guy ? definitely sounded edgier, on point and more combative speaking with reporters after a City Club of Chicago event. The guests inside the downtown Maggiano?s banquet hall included Rosemont Mayor Brad Stephens, who?s grabbed headlines by trying to lure the Cubs out to O?Hare International Airport. ?

Those kinds of ideas sounded like total non-starters ever since the Ricketts family finalized the $845 million purchase of the team ? as well as a stake in Comcast SportsNet Chicago ? from Tribune Co. in October 2009 and made repeated pledges to stay at Clark and Addison.

[MORE: Ricketts forced by Tribune to take on huge debt in Cubs purchase]

?We are committed to trying to work this out,? Ricketts said. ?We?ve always said that we want to win in Wrigley Field. But we also need to generate the revenue that we need to continue to compete as a franchise. And having the ability to put the video board or signs in the outfield is very important to us. It?s a primary focus of what we do going forward.?

The Cubs project they could make $20 million more annually in advertising revenue without the signage restrictions. They are also locked into a contract with the rooftop buildings that runs through the end of the 2023 season. They envision a 6,000-square-foot Jumbotron rising beyond left field.

Ricketts said the Cubs tried to ?minimize? the impact on the rooftops with these designs and didn?t sound at all concerned about a possible legal fight. The team filed development plans with the city on Wednesday, officially beginning what will be a series of public hearings, zoning negotiations and neighborhood meetings.

[RELATED: Sizing up the Cubs' video board proposal]

Beth Murphy ? the owner of Murphy?s Bleachers and spokesperson for the Wrigleyville Rooftops Association ??didn?t get a sneak peek and seemed to be still processing her first looks at the renderings. A reporter asked if her group is still considering a lawsuit.?

[MORE: Window closing if Cubs want to begin Wrigley renovation on time]

?I know you all want me to say that,? Murphy said. ?We have work to do with the Cubs. We haven?t had a seat at the table and we haven?t had legal representation.?

More than two weeks after announcing the ?framework? of an agreement with Mayor Rahm Emanuel and Alderman Tom Tunney, the Cubs still have to address a variety of neighborhood concerns, from the number of night games, to the size of the video board, to how Sheffield and Waveland would be used for street fests.

[PHOTOS: A look at proposed Wrigley Renovation project]

Murphy was asked if she viewed moving as an empty threat: ?I don?t think it would be a wise business decision.?

?The reason the Cubs are such a tourist destination,? Murphy said, ?is because it?s a ballpark in a neighborhood. (It?s) an interesting place for tourists to come to ? I don?t think a new ballpark in a parking lot is interesting.?

[RELATED: If the money's right, Wrigley will be a destination for free agents]

As these talks drag out ? team executives made a splashy presentation with sketches at Cubs Convention in January ? the baseball operations department risks losing the upgrades promised by Opening Day 2014.?

Ricketts confirmed that the new clubhouse, batting tunnels and training facilities depend on when the Cubs green light construction for the five consecutive offseasons it will take to complete the entire project.?

?We?ll know the timetable better when we get to the end of this process,? Ricketts said. ?That will really help us decide when we can do what.?

But the Cubs are not a flight risk. The Ricketts family has been strategically buying up property on the North Side, including the lot across from the Wrigley Field marquee, where the plan is to develop a 175-room hotel along with Starwood.??

?The Yankees are the most storied baseball franchise there is,? first baseman Anthony Rizzo said, ?and they tore down the original stadium and built a brand-new one. (This is) going to be something special.

?I know Mr. Ricketts wants to win. He?s building a winning environment here. He?s going to do whatever it takes to (do) what needs to be done. He wants to bring a championship here, whether it?s at Wrigley or not. We all want it to be at Wrigley.?

[MORE: Theo waiting for Wrigley deal, business plan, payrolls to come together]

Ricketts is playing hardball now, and that?s going to overshadow all the cool drawings for the future.

?Keep it in context,? Ricketts said. ?The talk of moving is relative to being able to have our flexibility in the outfield. I think everything else is going forward.?

Source: http://www.csnchicago.com/blog/cubs-talk/ricketts-threatens-move-cubs-without-ok-wrigley-signage

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Egypt investigates new student food poisoning case

CAIRO (AP) ? A security official says that Egyptian authorities are investigating a new case of food poisoning at Al-Azhar, Cairo's centuries-old seat of Sunni Muslim learning.

The official says the investigation opened Tuesday.

Some 160 university students fell sick after a tuna meal on Monday, sparking protests by colleagues angry over the quality of basic services in the university hostel, the official said. The students blocked the main road leading to the university, and security forces fired tear gas to quell the protest.

The official spoke on condition of anonymity because he was not authorized to speak to the press.

The university's president was fired earlier this month after the first case of poisoning.

Source: http://news.yahoo.com/egypt-investigates-student-food-poisoning-case-102626703.html

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